cswork / libraryOpen practice workspace

Interview guides · Synthego

Synthego Software Engineer Interview Guide

Synthego Software Engineer interview guide: reported rounds, questions and how candidates describe the process.

The 60-second brief

As a Software Engineer at Synthego, you play a crucial role in advancing the company's mission to facilitate the development of genetic engineering technologies. This position is integral to the design, development, and maintenance of software systems that support Synthego's innovative products in the biotech field. By leveraging modern software engineering principles, you will contribute to enhancing the efficiency and reliability of genetic research tools, which ultimately empower scientists to push the boundaries of synthetic biology. Your work will influence various aspects of product development, from system architecture to hands-on coding, all while collaborating with cross-functional teams. You will have the opportunity to solve complex technical challenges, innovate new solutions, and see your contributions directly impact the company's growth and the scientific community.

This guide is scoped to a Software Engineer candidate at Synthego.

Focus areas

  • Python
  • Coding Challenges (Algorithmic Coding)
  • Data Structures & Algorithms

The Synthego interview process

Synthego candidates report 3 rounds over 3-5 weeks. The stages below are what candidates describe, not a published process.

Phone Screen

Initial call with a recruiter to assess your background and fit for the role.

What to demonstrate

  • Initial call with a recruiter to assess your background and fit for the role
  • Depth in Python

How to prepare

  • Be able to walk your CV end to end in two minutes, and say why this company specifically.
  • Have your salary expectations, notice period and location constraints ready, and ask for the rest of the loop in writing.

Technical Interviews

Includes coding challenges and discussions with engineering managers.

What to demonstrate

  • Includes coding challenges and discussions with engineering managers
  • Depth in Python

How to prepare

  • Answer aloud and timed: Describe your experience with version control systems and how you manage code collaboration.
  • Answer aloud and timed: Solve a problem involving string manipulation and explain your thought process.

Behavioral Interviews

Explores your past experiences and how you collaborate with others.

What to demonstrate

  • Explores your past experiences and how you collaborate with others
  • Depth in Python

How to prepare

  • Prepare three examples from your own work, each with a decision you made and an outcome you can quantify.
  • Re-read the description of the behavioral interviews above and write down what you would ask to confirm before it.

Where candidates lose points

Prepare thoroughly

Ensure you practice coding and familiarize yourself with common algorithms and data structures relevant to the role.

Communicate effectively

Practice articulating your thought process during coding challenges, as interviewers place high value on clear communication.

Show enthusiasm for the mission

Be prepared to discuss how your personal values align with Synthego's mission and how you can contribute to it.

Engage with the interviewers

Ask thoughtful questions during interviews to demonstrate your interest in the role and company.

Questions & practice

Solve a problem involving string manipulation and explain your thought process.

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Given a set of data, how would you approach optimizing queries for performance?

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Write a function to check if a string is a palindrome.

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Stop tag and share joins from fanning out a page

Medium · join fan-out · semi-joins · many-to-many

resource_tag is (resource_id, tag_id) with PK (resource_id, tag_id); resource_share is (resource_id, shared_with_user_id, permission). The tagged-and-shared listing inner-joins resource to both, filters tenant_id, tag_id = ANY($2) and shared_with_user_id = $3, orders by updated_at DESC and takes 50. Pages come back with fewer than 50 distinct resources and the total in the header is far too high. Explain the row multiplication, rewrite both the page query and the count query so each is correct, and name the index each one needs. PostgreSQL 16.

Approach

  1. Do the arithmetic against the predicates that are actually there. An inner join emits one row per matching child row, and both joins are filtered: tag_id = ANY($2) admits only the requested tags, shared_with_user_id = $3 admits one user's share rows. So a resource holding three of the requested tags and shared with $3 once yields three rows, not one — the multiplier is its count of matching tags times its share rows for that single user, and that second factor is 1 unless the table admits duplicate (resource_id, shared_with_user_id) pairs. LIMIT 50 then limits rows rather than resources, and COUNT(*) counts pairs — the header is the product, not the population.
  2. Reject DISTINCT as the fix. It deduplicates after the product has been built, so the planner must materialise and sort the fanned-out set before the LIMIT can apply, and it leaves any SUM or AVG in the same select list wrong.
  3. Rewrite both filters as semi-joins, keeping resource as the only row source: AND EXISTS (SELECT 1 FROM resource_tag rt WHERE rt.resource_id = r.resource_id AND rt.tag_id = ANY($2)) and the same shape against resource_share. A semi-join stops at the first match per resource and preserves the driving index order, so ORDER BY updated_at DESC, resource_id DESC LIMIT 50 still stops after 50 rows.
  4. Count with the same predicates and no join at all: SELECT count(*) FROM resource r WHERE r.tenant_id = $1 AND r.status = 'active' AND EXISTS (...) AND EXISTS (...). Nothing multiplies a resource, so the number is the population.

Follow-up

  • The filter changes from 'any of these tags' to 'all of these tags'. Rewrite it and state what it costs relative to the ANY form.
  • A resource can be shared with the same user twice under different permissions. Does your count change, and should it?

Write the update path that detects a concurrent edit

Medium · optimistic concurrency · transactional outbox · audit history

resource carries version INT NOT NULL DEFAULT 1. resource_revision holds revision_id, resource_id, version, actor_user_id, change_kind, patch JSONB, request_id, created_at with UNIQUE (resource_id, version). outbox_event holds aggregate_type, aggregate_id, aggregate_version, event_type, payload, status. A PUT carries the version the client read. Write the exact statements for the single transaction that applies the edit, records the revision and enqueues 'resource.updated', and give the handler's branch on zero affected rows. Then say what PostgreSQL 16 does under READ COMMITTED when two of these updates hit one row at once.

Approach

  1. One transaction, three writes, no network call inside it: UPDATE resource SET title = $3, version = version + 1, updated_at = now() WHERE resource_id = $1 AND tenant_id = $4 AND version = $2; then INSERT the resource_revision row at version $2 + 1; then INSERT the outbox_event row at the same aggregate_version. The event goes to a table rather than a broker because no transaction spans both.
  2. Branch on the affected-row count before doing anything else. Zero has three causes — stale version, wrong tenant, row gone — so re-read once and map to 409 carrying the current version, or 404 for an id outside the caller's tenant, which also stops the endpoint confirming that another tenant's id exists.
  3. State the engine behaviour instead of assuming it. Under READ COMMITTED the second UPDATE blocks on the row lock, and when the first commits PostgreSQL re-evaluates the WHERE clause against the newly committed row, so the version predicate now fails and the statement reports zero rows. Under REPEATABLE READ the identical collision raises SQLSTATE 40001 instead, so the handler must fold both shapes into one conflict response.
  4. Keep UNIQUE (resource_id, version) even though the predicate already serialises writers. It is what makes a lost update unwritable if any other path ever reaches the revision table, and it converts a logic bug into 23505 rather than into a silently missing history row.

Follow-up

  • A client sends the version it read ten minutes ago and the resource has moved three versions. What is in your 409 so it can resolve the conflict without a full re-fetch?
  • Two editors, two disjoint fields, no overlap. Does your answer still refuse the second write, and should it?

What programming languages are you most proficient in, and how have you applied them in previous projects?

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

Can you explain a complex technical problem you solved and the approach you took?

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

How would you design a system to handle large volumes of genomic data?

Medium · System Design / Architecture

Approach

  1. Fix the scope first: who calls this, how often, and what they do when it fails.
  2. Name the read and write paths separately; they rarely have the same bottleneck.
  3. Choose a partition key and say what query it makes expensive.
  4. State the consistency you need, and where you are willing to be stale.

Follow-up

  • What breaks first when traffic grows ten times?
  • How does this behave when that dependency is down for an hour?

Describe your approach to ensuring software quality and reliability in your designs.

Medium · System Design / Architecture

Approach

  1. Fix the scope first: who calls this, how often, and what they do when it fails.
  2. Name the read and write paths separately; they rarely have the same bottleneck.
  3. Choose a partition key and say what query it makes expensive.
  4. State the consistency you need, and where you are willing to be stale.

Follow-up

  • What breaks first when traffic grows ten times?
  • How does this behave when that dependency is down for an hour?

What considerations do you take into account when designing APIs?

Medium · System Design / Architecture

Approach

  1. Fix the scope first: who calls this, how often, and what they do when it fails.
  2. Name the read and write paths separately; they rarely have the same bottleneck.
  3. Choose a partition key and say what query it makes expensive.
  4. State the consistency you need, and where you are willing to be stale.

Follow-up

  • What breaks first when traffic grows ten times?
  • How does this behave when that dependency is down for an hour?

One customer endpoint stalls deliveries to every other destination

Medium · bulkhead · timeouts · saturation

The egress service delivers about 1.5k webhooks/second across 40,000 destinations, with a per-destination concurrency cap of 4 and a 10-second connect-plus-read timeout. Throughput falls to 300/second, queue depth climbs, and p99 delivery latency for unaffected destinations goes from 200 ms to minutes, while the error rate barely moves. One tenant holds 900 destination rows whose URLs share a hostname that now answers in 9.5 seconds. Explain the mechanism with the arithmetic, then give the containment in the order you would apply it.

Approach

  1. Look at saturation before errors. A flat error rate with collapsing throughput says nothing is failing, things are waiting, so the first signal to pull is in-flight request count or pool wait time rather than the error counter. This is the distinction that decides the whole investigation.
  2. Group in-flight work by resolved host, not by destination id. The cap is keyed per destination row, so 900 rows sharing one hostname buy 3,600 concurrent slots against a single host, each held for 9.5 seconds. The bulkhead was never a bulkhead for that host, and grouping by the wrong dimension is why the dashboard looked healthy.
  3. Do the arithmetic in both directions. Required concurrency is arrival rate times latency, so 1.5k/second at 200 ms needs about 300 in flight, which is entirely consumed by 3,600 slow slots; conversely whatever concurrency is left sustains rate equals concurrency divided by 9.5 seconds, which is the 300/second you are seeing. Matching both numbers is what promotes this from a plausible story to the mechanism.
  4. Explain why the circuit breaker never helped. It opens on consecutive failures, and a 9.5-second response inside a 10-second timeout is a success. Slow is not failing, so an error-rate breaker cannot see this; you need a slow-call ratio, a deadline propagated from the caller's remaining budget, or a concurrency limiter.

Follow-up

  • The host recovers to 80 ms. How long does the queue take to drain, and what does the drain do to the recovered host?
  • Where should the 10-second timeout number actually come from?

Suggested practice checklist

Built from the rounds and topics Synthego candidates report.

Day 1 — Map the Synthego loop

  • Write out the reported sequence: Phone Screen, Technical Interviews, Behavioral Interviews.
  • For each round, write one sentence on what it is judging, from the description above, and mark the one you are least ready for.

Deliverable: A one-page map of the 3 reported rounds, with the weakest marked.

Day 2 — Work Python

  • Spend the session on Python, which Synthego candidates report being tested on.
  • Write one worked example in Python and time yourself on it.

Deliverable: One timed worked example in Python.

Day 3 — Work Coding Challenges (Algorithmic Coding)

  • Spend the session on Coding Challenges (Algorithmic Coding), which Synthego candidates report being tested on.
  • Write one worked example in Coding Challenges (Algorithmic Coding) and time yourself on it.

Deliverable: One timed worked example in Coding Challenges (Algorithmic Coding).

Day 4 — Work Data Structures & Algorithms

  • Spend the session on Data Structures & Algorithms, which Synthego candidates report being tested on.
  • Write one worked example in Data Structures & Algorithms and time yourself on it.

Deliverable: One timed worked example in Data Structures & Algorithms.

Day 5 — Answer out loud: Technical / Domain Questions

  • Answer aloud, timed: What programming languages are you most proficient in, and how have you applied them in previous projects?
  • Answer aloud, timed: Can you explain a complex technical problem you solved and the approach you took?

Deliverable: Spoken answers to 2 reported Technical / Domain Questions question(s), under time.

Day 6 — Answer out loud: Coding / Algorithms

  • Answer aloud, timed: Solve a problem involving string manipulation and explain your thought process.
  • Answer aloud, timed: Given a set of data, how would you approach optimizing queries for performance?

Deliverable: Spoken answers to 2 reported Coding / Algorithms question(s), under time.

Day 7 — Answer out loud: Behavioral / Leadership

  • Answer aloud, timed: Tell us about a time when you faced a significant challenge in a project. How did you handle it?
  • Answer aloud, timed: How do you prioritize tasks when working on multiple projects with tight deadlines?

Deliverable: Spoken answers to 2 reported Behavioral / Leadership question(s), under time.

Behavioural preparation

Behavioural rounds judge the decision you made and what it cost.

Describe your experience with version control systems and how you manage code collaboration.

Medium · Technical / Domain Questions

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

Tell us about a time when you faced a significant challenge in a project. How did you handle it?

Medium · Behavioral / Leadership

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

How do you prioritize tasks when working on multiple projects with tight deadlines?

Medium · Behavioral / Leadership

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

Describe a situation where you had to work with a difficult team member. How did you manage that relationship?

Medium · Behavioral / Leadership

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?