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Sarepta Therapeutics Software Engineer Interview Guide

Sarepta Therapeutics Software Engineer interview guide: reported rounds, questions and how candidates describe the process.

The 60-second brief

The role of a Software Engineer at Sarepta Therapeutics is pivotal in driving innovation within the biopharmaceutical industry. As a Software Engineer, you will be responsible for developing software solutions that support the research and development of genetic medicines, ultimately impacting the lives of patients with rare diseases. Your work will be instrumental in ensuring that complex data systems are reliable, efficient, and scalable, thereby enhancing the company's ability to deliver critical therapies. This position is not only about coding; it involves collaborating with multidisciplinary teams, including scientists and clinical researchers, to create software that meets regulatory standards and supports cutting-edge research.

This guide is scoped to a Software Engineer candidate at Sarepta Therapeutics.

Focus areas

  • Clinical Supply Chain Engineering (Domain)
  • Supply Chain Engineering
  • Software Engineering (General)

The Sarepta Therapeutics interview process

Sarepta Therapeutics candidates report 3 rounds over 3-5 weeks. The stages below are what candidates describe, not a published process.

Phone Screening

Initial phone screening with a hiring manager to assess candidate fit.

What to demonstrate

  • Initial phone screening with a hiring manager to assess candidate fit
  • Depth in Clinical Supply Chain Engineering (Domain)

How to prepare

  • Be able to walk your CV end to end in two minutes, and say why this company specifically.
  • Have your salary expectations, notice period and location constraints ready, and ask for the rest of the loop in writing.

Seminar Presentation

Candidates may be required to present a seminar as part of the interview process.

What to demonstrate

  • Candidates may be required to present a seminar as part of the interview process
  • Depth in Clinical Supply Chain Engineering (Domain)

How to prepare

  • Answer aloud and timed: Describe a challenging technical problem you encountered and how you solved it.
  • Answer aloud and timed: How do you ensure code quality and maintainability in your projects?

One-on-One Interviews

Multiple one-on-one interviews with team members to evaluate technical and cultural fit.

What to demonstrate

  • Multiple one-on-one interviews with team members to evaluate technical and cultural fit
  • Depth in Clinical Supply Chain Engineering (Domain)

How to prepare

  • Answer aloud and timed: What experience do you have with data structures and algorithms, and can you provide examples of how you have utilized them?
  • Answer aloud and timed: How would you architect a system to handle large-scale genomic data processing?

Where candidates lose points

Research the Company

Understand Sarepta Therapeutics's mission and recent projects to demonstrate your alignment with their goals.

Practice Coding Challenges

Prepare for technical interviews by practicing coding problems and system design scenarios relevant to your role.

Behavioral Questions

Prepare structured responses using the STAR method (Situation, Task, Action, Result) to effectively communicate your experiences.

Ask Insightful Questions

Engage your interviewers with thoughtful questions about the team and company culture, showing your genuine interest in the role.

Questions & practice

What experience do you have with data structures and algorithms, and can you provide examples of how you have

Medium · Technical / Domain Questions

What experience do you have with data structures and algorithms, and can you provide examples of how you have utilized them?

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Write a function to reverse a linked list.

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Implement a binary search algorithm and explain its time complexity.

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Solve a coding problem related to string manipulation.

Medium · Coding / Algorithms

Approach

  1. Restate the input: its shape, its size, and what is guaranteed about it.
  2. Name the brute-force solution and its complexity before improving on it.
  3. Choose the data structure from the access pattern, not from familiarity.
  4. State the target complexity and say which constraint rules the naive version out.

Follow-up

  • How does this change if the input no longer fits in memory?
  • What is the worst case, and how likely is it on real data?

Find version gaps and relay lag with window functions

Medium · window functions · event tables · frame semantics

outbox_event holds event_id, aggregate_type, aggregate_id, aggregate_version, event_type, payload, status ('pending','published','dead'), attempts, created_at, published_at. A projection is missing rows and you must decide whether the relay skipped events or the consumer dropped them. Write three queries over the last seven days: one listing every aggregate_id whose published aggregate_version sequence has a hole, one giving per-day counts with a running total, and one returning the newest published event per aggregate. For each, say where the window function is evaluated relative to WHERE and LIMIT. PostgreSQL 16.

Approach

  1. Gaps: compute lead(aggregate_version) OVER (PARTITION BY aggregate_id ORDER BY aggregate_version) in a subquery, then filter next_version <> aggregate_version + 1 in the outer query. Window functions are evaluated after WHERE, GROUP BY and HAVING and before the outer ORDER BY and LIMIT, so the predicate cannot sit in the same WHERE clause and PostgreSQL 16 has no QUALIFY.
  2. Say what the seven-day filter does to the answer: it truncates every partition, so the first row per aggregate has no predecessor inside the window and a hole spanning the boundary is invisible. Widen the window, or join to resource.version as the authority for the true maximum.
  3. Running total: SELECT date_trunc('day', created_at) AS d, count() AS n, sum(count()) OVER (ORDER BY date_trunc('day', created_at) ROWS UNBOUNDED PRECEDING). An aggregate inside a window call is legal because grouping runs before windowing. The grouping key is unique per row here so ROWS and RANGE agree, but write the frame anyway — over ungrouped rows with tied timestamps the default RANGE frame pulls in every peer row and the total jumps.
  4. Newest per aggregate: DISTINCT ON (aggregate_id) ... ORDER BY aggregate_id, aggregate_version DESC is the cheap PostgreSQL-only form when an index matches that order; row_number() OVER (PARTITION BY aggregate_id ORDER BY aggregate_version DESC) = 1 is the portable form and needs a subquery for the same evaluation-order reason as the gap query.

Follow-up

  • Relay failover redelivers events. Does a duplicate break the gap query, and how would you detect one from this table alone?
  • Turn the gap check into a continuous monitor rather than a query someone runs after an incident. What does it watch?

Write the update path that detects a concurrent edit

Medium · optimistic concurrency · transactional outbox · audit history

resource carries version INT NOT NULL DEFAULT 1. resource_revision holds revision_id, resource_id, version, actor_user_id, change_kind, patch JSONB, request_id, created_at with UNIQUE (resource_id, version). outbox_event holds aggregate_type, aggregate_id, aggregate_version, event_type, payload, status. A PUT carries the version the client read. Write the exact statements for the single transaction that applies the edit, records the revision and enqueues 'resource.updated', and give the handler's branch on zero affected rows. Then say what PostgreSQL 16 does under READ COMMITTED when two of these updates hit one row at once.

Approach

  1. One transaction, three writes, no network call inside it: UPDATE resource SET title = $3, version = version + 1, updated_at = now() WHERE resource_id = $1 AND tenant_id = $4 AND version = $2; then INSERT the resource_revision row at version $2 + 1; then INSERT the outbox_event row at the same aggregate_version. The event goes to a table rather than a broker because no transaction spans both.
  2. Branch on the affected-row count before doing anything else. Zero has three causes — stale version, wrong tenant, row gone — so re-read once and map to 409 carrying the current version, or 404 for an id outside the caller's tenant, which also stops the endpoint confirming that another tenant's id exists.
  3. State the engine behaviour instead of assuming it. Under READ COMMITTED the second UPDATE blocks on the row lock, and when the first commits PostgreSQL re-evaluates the WHERE clause against the newly committed row, so the version predicate now fails and the statement reports zero rows. Under REPEATABLE READ the identical collision raises SQLSTATE 40001 instead, so the handler must fold both shapes into one conflict response.
  4. Keep UNIQUE (resource_id, version) even though the predicate already serialises writers. It is what makes a lost update unwritable if any other path ever reaches the revision table, and it converts a logic bug into 23505 rather than into a silently missing history row.

Follow-up

  • A client sends the version it read ten minutes ago and the resource has moved three versions. What is in your 409 so it can resolve the conflict without a full re-fetch?
  • Two editors, two disjoint fields, no overlap. Does your answer still refuse the second write, and should it?

What programming languages are you proficient in, and how have you applied them in previous projects?

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

Can you explain the software development lifecycle and your approach to each stage?

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

Describe a challenging technical problem you encountered and how you solved it.

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

How do you ensure code quality and maintainability in your projects?

Medium · Technical / Domain Questions

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

How would you architect a system to handle large-scale genomic data processing?

Medium · System Design / Architecture

Approach

  1. Fix the scope first: who calls this, how often, and what they do when it fails.
  2. Name the read and write paths separately; they rarely have the same bottleneck.
  3. Choose a partition key and say what query it makes expensive.
  4. State the consistency you need, and where you are willing to be stale.

Follow-up

  • What breaks first when traffic grows ten times?
  • How does this behave when that dependency is down for an hour?

What design patterns do you frequently use, and why?

Medium · System Design / Architecture

Approach

  1. Fix the scope first: who calls this, how often, and what they do when it fails.
  2. Name the read and write paths separately; they rarely have the same bottleneck.
  3. Choose a partition key and say what query it makes expensive.
  4. State the consistency you need, and where you are willing to be stale.

Follow-up

  • What breaks first when traffic grows ten times?
  • How does this behave when that dependency is down for an hour?

You are given a dataset with missing values. How would you handle this data before analysis?

Medium · Problem-Solving / Case Studies

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

How would you approach optimizing a slow-running application?

Medium · Problem-Solving / Case Studies

Approach

  1. Clarify what is being asked and what a complete answer contains.
  2. State your assumptions explicitly before working the problem.
  3. Say what you would check first and why it is the highest-information step.
  4. Work from the requirement backwards to the design.

Follow-up

  • What assumption would you test first?
  • How would you know your answer was wrong?

One customer endpoint stalls deliveries to every other destination

Medium · bulkhead · timeouts · saturation

The egress service delivers about 1.5k webhooks/second across 40,000 destinations, with a per-destination concurrency cap of 4 and a 10-second connect-plus-read timeout. Throughput falls to 300/second, queue depth climbs, and p99 delivery latency for unaffected destinations goes from 200 ms to minutes, while the error rate barely moves. One tenant holds 900 destination rows whose URLs share a hostname that now answers in 9.5 seconds. Explain the mechanism with the arithmetic, then give the containment in the order you would apply it.

Approach

  1. Look at saturation before errors. A flat error rate with collapsing throughput says nothing is failing, things are waiting, so the first signal to pull is in-flight request count or pool wait time rather than the error counter. This is the distinction that decides the whole investigation.
  2. Group in-flight work by resolved host, not by destination id. The cap is keyed per destination row, so 900 rows sharing one hostname buy 3,600 concurrent slots against a single host, each held for 9.5 seconds. The bulkhead was never a bulkhead for that host, and grouping by the wrong dimension is why the dashboard looked healthy.
  3. Do the arithmetic in both directions. Required concurrency is arrival rate times latency, so 1.5k/second at 200 ms needs about 300 in flight, which is entirely consumed by 3,600 slow slots; conversely whatever concurrency is left sustains rate equals concurrency divided by 9.5 seconds, which is the 300/second you are seeing. Matching both numbers is what promotes this from a plausible story to the mechanism.
  4. Explain why the circuit breaker never helped. It opens on consecutive failures, and a 9.5-second response inside a 10-second timeout is a success. Slow is not failing, so an error-rate breaker cannot see this; you need a slow-call ratio, a deadline propagated from the caller's remaining budget, or a concurrency limiter.

Follow-up

  • The host recovers to 80 ms. How long does the queue take to drain, and what does the drain do to the recovered host?
  • Where should the 10-second timeout number actually come from?

Suggested practice checklist

Built from the rounds and topics Sarepta Therapeutics candidates report.

Day 1 — Map the Sarepta Therapeutics loop

  • Write out the reported sequence: Phone Screening, Seminar Presentation, One-on-One Interviews.
  • For each round, write one sentence on what it is judging, from the description above, and mark the one you are least ready for.

Deliverable: A one-page map of the 3 reported rounds, with the weakest marked.

Day 2 — Work Clinical Supply Chain Engineering (Domain)

  • Spend the session on Clinical Supply Chain Engineering (Domain), which Sarepta Therapeutics candidates report being tested on.
  • Write one worked example in Clinical Supply Chain Engineering (Domain) and time yourself on it.

Deliverable: One timed worked example in Clinical Supply Chain Engineering (Domain).

Day 3 — Work Supply Chain Engineering

  • Spend the session on Supply Chain Engineering, which Sarepta Therapeutics candidates report being tested on.
  • Write one worked example in Supply Chain Engineering and time yourself on it.

Deliverable: One timed worked example in Supply Chain Engineering.

Day 4 — Work Software Engineering (General)

  • Spend the session on Software Engineering (General), which Sarepta Therapeutics candidates report being tested on.
  • Write one worked example in Software Engineering (General) and time yourself on it.

Deliverable: One timed worked example in Software Engineering (General).

Day 5 — Answer out loud: Technical / Domain Questions

  • Answer aloud, timed: What programming languages are you proficient in, and how have you applied them in previous projects?
  • Answer aloud, timed: Can you explain the software development lifecycle and your approach to each stage?

Deliverable: Spoken answers to 2 reported Technical / Domain Questions question(s), under time.

Day 6 — Answer out loud: System Design / Architecture

  • Answer aloud, timed: How would you architect a system to handle large-scale genomic data processing?
  • Answer aloud, timed: Describe a time when you had to make architectural decisions for a complex software project.

Deliverable: Spoken answers to 2 reported System Design / Architecture question(s), under time.

Day 7 — Answer out loud: Behavioral / Leadership

  • Answer aloud, timed: Describe a situation where you had to work collaboratively with a difficult team member. How did you handle it?
  • Answer aloud, timed: How do you prioritize tasks when working on multiple projects simultaneously?

Deliverable: Spoken answers to 2 reported Behavioral / Leadership question(s), under time.

Behavioural preparation

Behavioural rounds judge the decision you made and what it cost.

Describe a time when you had to make architectural decisions for a complex software project.

Medium · System Design / Architecture

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

Describe a situation where you had to work collaboratively with a difficult team member. How did you handle it

Medium · Behavioral / Leadership

Describe a situation where you had to work collaboratively with a difficult team member. How did you handle it?

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

How do you prioritize tasks when working on multiple projects simultaneously?

Medium · Behavioral / Leadership

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?

Give an example of how you have influenced a team or project positively.

Medium · Behavioral / Leadership

Approach

  1. Pick a story where you made the decision, not one where you watched it.
  2. State the situation in two sentences and spend the rest on the reasoning.
  3. Give the blast radius: what could have broken, and what you measured.
  4. Name the disagreement and how you resolved it with evidence.

Follow-up

  • What would you do differently if you ran that again?
  • How did you know your change caused the improvement?