Interview guides · Caris Life Sciences

Caris Life Sciences Software Engineer Interview Guide

Caris Life Sciences Software Engineer interview guide: reported rounds, questions and how candidates describe the process.

The 60-second brief

A Software Engineer at Caris Life Sciences plays a critical role in the revolution of precision medicine. Caris Life Sciences is a leading innovator in molecular science and artificial intelligence, focused on delivering actively personalized medicine to cancer patients. As an engineer in this space, you are not just writing code; you are building the highly scalable data pipelines, advanced laboratory information management systems (LIMS), and clinical trial matching platforms that process massive genomic, transcriptomic, and proteomic datasets. The impact of your work is direct and profound. The software systems you design and maintain enable pathologists, oncologists, and researchers to interpret complex molecular profiles, helping them make life-saving treatment decisions for patients worldwide.

This guide is scoped to a Software Engineer candidate at Caris Life Sciences.

Focus areas

Technical interview (general)
Technical interview preparation
Problem solving skills

The Caris Life Sciences interview process

Caris Life Sciences candidates report 3 rounds over 3-5 weeks. The stages below are what candidates describe, not a published process.

Recruiter Phone Screen

A standard 30-minute call to discuss your background, experience with engineering tools, and salary expectations.

What to demonstrate

A standard 30-minute call to discuss your background, experience with engineering tools, and salary expectations
Depth in Technical interview (general)

How to prepare

Be able to walk your CV end to end in two minutes, and say why this company specifically.
Have your salary expectations, notice period and location constraints ready, and ask for the rest of the loop in writing.

Technical Phone Screen

A 1-hour interview with a hiring manager or VP focusing on technical discussions, architectural concepts, and a deep dive into your resume.

What to demonstrate

A 1-hour interview with a hiring manager or VP focusing on technical discussions, architectural concepts, and a deep dive into your resume
Depth in Technical interview (general)

How to prepare

Be able to walk your CV end to end in two minutes, and say why this company specifically.
Have your salary expectations, notice period and location constraints ready, and ask for the rest of the loop in writing.

Virtual On-Site Interview

Multiple rounds with different team members covering deep technical design questions and behavioral assessments.

What to demonstrate

Multiple rounds with different team members covering deep technical design questions and behavioral assessments
Depth in Technical interview (general)

How to prepare

Answer aloud and timed: Walk me through the most technically challenging software project you have designed and implemented. What were the bottlenecks, and how did you resolve them?
Answer aloud and timed: Tell me about a time you had to refactor a legacy system. What was your strategy for ensuring zero downtime or data loss?

Where candidates lose points

Know your resume inside out

Because the technical evaluations are deeply rooted in your past experience, you should be ready to discuss any technology, framework, or architectural pattern mentioned on your resume. Be honest about your contributions and ready to explain the "why" behind your choices.

Emphasize practical scalability

When discussing system design, focus on real-world constraints such as data consistency, network latency, security, and cost-efficiency rather than purely theoretical models.

Show passion for the mission

Caris Life Sciences is dedicated to fighting cancer. Expressing a genuine interest in how your software engineering skills can contribute to precision medicine and patient care will set you apart from other candidates.

Questions & practice

Collapse a redelivered event batch into per-aggregate high-water marks

Easy · hashing · at-least-once · aggregation

You drain a batch of up to 5,000,000 events, each (aggregate_id BIGINT, aggregate_version INT, event_type, payload). The log guarantees order within one aggregate only; the batch merges 64 partitions, and a relay failover has redelivered a range, so an older version for an aggregate can appear after a newer one. Given a map of last_applied_version per aggregate, produce the events worth applying, at most one per (aggregate_id, version), plus the count discarded. Target O(n) time. State the memory for 2,000,000 distinct aggregates and what you do when it does not fit.

Approach

One pass, one hash map from aggregate_id to the highest version kept, and a discard counter. An event whose version is at or below last_applied_version for its aggregate is dropped without further work, which is the whole reason the event carries its version rather than a delta. O(n) expected time, O(d) space in distinct aggregates.
Keep the maximum, never the last occurrence. The redelivered range means the final appearance of an aggregate in the batch can be an older version than one seen earlier in the same batch, so last-wins applies stale state over newer state and the projection regresses with no error anywhere.
Cost the memory instead of calling it large: an 8-byte key plus a 4-byte version is 12 bytes of payload, and an open-addressed table held at a 0.7 load factor costs roughly 17 bytes per entry before per-slot metadata, so 2,000,000 aggregates is tens of megabytes in a native layout and several times that in a runtime that boxes both key and value.
If the distinct set exceeds memory, partition on hash(aggregate_id) mod P and reduce each partition independently. Every event for one aggregate hashes to the same partition, so the per-partition result is exact and the merge is concatenation rather than a second reduction.

Follow-up

The payload is a patch rather than a snapshot, so applying only the highest version loses the intermediate changes. What changes in your reduction?
How do you detect that version 7 arrived while version 6 was never delivered, and what should the consumer do about the gap?

Find overlapping job attempts and peak concurrency from lease records

Medium · sweep line · intervals · leases

A day of job_run history yields about 50,000,000 attempt records: (job_run_id, job_type, attempt, started_at, finished_at which is NULL when the worker died, lease_expires_at). Leases expire on a clock, so a job that outran its lease ran twice. Produce (a) every job_run_id whose attempts overlapped in wall-clock time and (b) the peak number of simultaneously running attempts per job_type with the minute it occurred. Target O(n log n). State how you treat a NULL finished_at and what clock skew does to your answer.

Approach

Define the interval before sorting anything: an attempt occupies [started_at, COALESCE(finished_at, lease_expires_at)). finished_at is observed and lease_expires_at is only a promise, so every attempt without a finish contributes an estimate and the whole result is a lower bound on overlap rather than an exact count.
For peak concurrency, sweep: emit 2n endpoints, sort by (timestamp, kind) with ends ordered before starts at equal timestamps, then walk the sequence maintaining a counter per job_type and record each type's maximum with its timestamp. O(n log n) dominated by the sort, O(n) space, or O(1) extra if the sort is external and the walk streams.
For overlap detection, do not compare attempts pairwise. A single global sort by (job_run_id, started_at) gives both the grouping and the order; within a group, keep the maximum end seen so far and report an overlap exactly when the next start is less than that running maximum, which is one linear pass after the sort.
Half-open intervals matter and are easy to get wrong: with closed intervals an attempt ending at the same millisecond another begins reads as concurrency two, and across 50,000,000 records that artefact swamps the real signal.

Follow-up

A handler is not idempotent and you have found 400 overlapping jobs. Which of them actually caused damage, and what would you query to find out?
Peak concurrency for one job_type is 4 against a configured cap of 4. Is the cap working, or is the data hiding attempts that never started?

Track a rolling failure rate per destination for circuit decisions

Easy · sliding window · ring buffer · circuit breaker

The egress service delivers about 1,500 webhooks per second across roughly 40,000 destinations, each call bounded by a 10 second timeout. Maintain, per destination, the failure rate over the trailing 60 seconds so a caller can ask before dispatch whether the circuit should open. Attempts arrive as (destination_id, finished_at_ms, outcome). Requirement: amortised O(1) per attempt, with total memory bounded by the destination count rather than by traffic. Give the structure, its exact memory, and the rule that stops a destination with three attempts from opening a circuit.

Approach

Name the exact-deque version and then reject it as the default. Holding timestamps and advancing a tail pointer past anything older than now minus 60 seconds is a correct two-pointer window at amortised O(1) per attempt, but its memory tracks in-window traffic, so one destination in a retry storm holds hundreds of thousands of entries while thousands of quiet destinations hold none.
Use a ring of 60 one-second buckets per destination, each bucket a pair of counters for attempts and failures. On an attempt, advance the ring by the elapsed whole seconds, zeroing at most min(elapsed, 60) buckets, then increment the head. That is amortised O(1) with a fixed footprint per destination.
State the footprint: 60 buckets times two 4-byte counters is 480 bytes of payload per destination, so 40,000 destinations is roughly 20 to 25 MB with per-entry overhead, bounded by the catalogue rather than by the rate. The cost is granularity, since the oldest bucket ages out in whole seconds, which is far tighter than the decision needs.
Require a minimum sample before the circuit may open. A destination with three attempts and three failures reads as 100 percent and is not evidence; a floor of roughly 20 attempts in the window makes the ratio meaningful, and below that floor use a run of consecutive failures as the trigger instead.

Follow-up

The fleet is 30 instances and each sees roughly a thirtieth of a destination's traffic. Where does the rate actually live, and what does a per-instance answer get wrong?
A destination answers in 9.5 seconds and succeeds. It is not failing but it is consuming your per-destination concurrency. What signal should open the circuit here?

Write the update path that detects a concurrent edit

Medium · optimistic concurrency · transactional outbox · audit history

resource carries version INT NOT NULL DEFAULT 1. resource_revision holds revision_id, resource_id, version, actor_user_id, change_kind, patch JSONB, request_id, created_at with UNIQUE (resource_id, version). outbox_event holds aggregate_type, aggregate_id, aggregate_version, event_type, payload, status. A PUT carries the version the client read. Write the exact statements for the single transaction that applies the edit, records the revision and enqueues 'resource.updated', and give the handler's branch on zero affected rows. Then say what PostgreSQL 16 does under READ COMMITTED when two of these updates hit one row at once.

Approach

One transaction, three writes, no network call inside it: UPDATE resource SET title = $3, version = version + 1, updated_at = now() WHERE resource_id = $1 AND tenant_id = $4 AND version = $2; then INSERT the resource_revision row at version $2 + 1; then INSERT the outbox_event row at the same aggregate_version. The event goes to a table rather than a broker because no transaction spans both.
Branch on the affected-row count before doing anything else. Zero has three causes — stale version, wrong tenant, row gone — so re-read once and map to 409 carrying the current version, or 404 for an id outside the caller's tenant, which also stops the endpoint confirming that another tenant's id exists.
State the engine behaviour instead of assuming it. Under READ COMMITTED the second UPDATE blocks on the row lock, and when the first commits PostgreSQL re-evaluates the WHERE clause against the newly committed row, so the version predicate now fails and the statement reports zero rows. Under REPEATABLE READ the identical collision raises SQLSTATE 40001 instead, so the handler must fold both shapes into one conflict response.
Keep UNIQUE (resource_id, version) even though the predicate already serialises writers. It is what makes a lost update unwritable if any other path ever reaches the revision table, and it converts a logic bug into 23505 rather than into a silently missing history row.

Follow-up

A client sends the version it read ten minutes ago and the resource has moved three versions. What is in your 409 so it can resolve the conflict without a full re-fetch?
Two editors, two disjoint fields, no overlap. Does your answer still refuse the second write, and should it?

Find version gaps and relay lag with window functions

Medium · window functions · event tables · frame semantics

outbox_event holds event_id, aggregate_type, aggregate_id, aggregate_version, event_type, payload, status ('pending','published','dead'), attempts, created_at, published_at. A projection is missing rows and you must decide whether the relay skipped events or the consumer dropped them. Write three queries over the last seven days: one listing every aggregate_id whose published aggregate_version sequence has a hole, one giving per-day counts with a running total, and one returning the newest published event per aggregate. For each, say where the window function is evaluated relative to WHERE and LIMIT. PostgreSQL 16.

Approach

Gaps: compute lead(aggregate_version) OVER (PARTITION BY aggregate_id ORDER BY aggregate_version) in a subquery, then filter next_version <> aggregate_version + 1 in the outer query. Window functions are evaluated after WHERE, GROUP BY and HAVING and before the outer ORDER BY and LIMIT, so the predicate cannot sit in the same WHERE clause and PostgreSQL 16 has no QUALIFY.
Say what the seven-day filter does to the answer: it truncates every partition, so the first row per aggregate has no predecessor inside the window and a hole spanning the boundary is invisible. Widen the window, or join to resource.version as the authority for the true maximum.
Running total: SELECT date_trunc('day', created_at) AS d, count() AS n, sum(count()) OVER (ORDER BY date_trunc('day', created_at) ROWS UNBOUNDED PRECEDING). An aggregate inside a window call is legal because grouping runs before windowing. The grouping key is unique per row here so ROWS and RANGE agree, but write the frame anyway — over ungrouped rows with tied timestamps the default RANGE frame pulls in every peer row and the total jumps.
Newest per aggregate: DISTINCT ON (aggregate_id) ... ORDER BY aggregate_id, aggregate_version DESC is the cheap PostgreSQL-only form when an index matches that order; row_number() OVER (PARTITION BY aggregate_id ORDER BY aggregate_version DESC) = 1 is the portable form and needs a subquery for the same evaluation-order reason as the gap query.

Follow-up

Relay failover redelivers events. Does a duplicate break the gap query, and how would you detect one from this table alone?
Turn the gap check into a continuous monitor rather than a query someone runs after an incident. What does it watch?

What software engineering tools, frameworks, and languages are you currently using in your day-to-day work, an

Medium · Practical Technical Experience & Tooling

What software engineering tools, frameworks, and languages are you currently using in your day-to-day work, and why?

Approach

Clarify what is being asked and what a complete answer contains.
State your assumptions explicitly before working the problem.
Say what you would check first and why it is the highest-information step.
Work from the requirement backwards to the design.

Follow-up

What assumption would you test first?
How would you know your answer was wrong?

How do you approach choosing the right database (SQL vs. NoSQL) for a high-throughput, data-heavy application?

Medium · Practical Technical Experience & Tooling

Approach

Fix the scope first: who calls this, how often, and what they do when it fails.
Name the read and write paths separately; they rarely have the same bottleneck.
Choose a partition key and say what query it makes expensive.
State the consistency you need, and where you are willing to be stale.

Follow-up

What breaks first when traffic grows ten times?
How does this behave when that dependency is down for an hour?

Explain how you manage dependencies and ensure environment consistency across development, testing, and produc

Medium · Practical Technical Experience & Tooling

Explain how you manage dependencies and ensure environment consistency across development, testing, and production environments.

Approach

Clarify what is being asked and what a complete answer contains.
State your assumptions explicitly before working the problem.
Say what you would check first and why it is the highest-information step.
Work from the requirement backwards to the design.

Follow-up

What assumption would you test first?
How would you know your answer was wrong?

Walk me through the most technically challenging software project you have designed and implemented. What were

Medium · Resume & Project Deep Dives

Walk me through the most technically challenging software project you have designed and implemented. What were the bottlenecks, and how did you resolve them?

Approach

Clarify what is being asked and what a complete answer contains.
State your assumptions explicitly before working the problem.
Say what you would check first and why it is the highest-information step.
Work from the requirement backwards to the design.

Follow-up

What assumption would you test first?
How would you know your answer was wrong?

Describe a situation where you had to make a significant architectural trade-off. Why did you make that choice

Medium · Resume & Project Deep Dives

Describe a situation where you had to make a significant architectural trade-off. Why did you make that choice, and what was the long-term impact?

Approach

Fix the scope first: who calls this, how often, and what they do when it fails.
Name the read and write paths separately; they rarely have the same bottleneck.
Choose a partition key and say what query it makes expensive.
State the consistency you need, and where you are willing to be stale.

Follow-up

What breaks first when traffic grows ten times?
How does this behave when that dependency is down for an hour?

How have you handled data security and privacy compliance (such as HIPAA or GDPR) in your past software develo

Medium · Resume & Project Deep Dives

How have you handled data security and privacy compliance (such as HIPAA or GDPR) in your past software development projects?

Approach

Clarify what is being asked and what a complete answer contains.
State your assumptions explicitly before working the problem.
Say what you would check first and why it is the highest-information step.
Work from the requirement backwards to the design.

Follow-up

What assumption would you test first?
How would you know your answer was wrong?

Listing latency scales with page size, not with filters

Easy · n+1 · latency · query batching

The tenant listing endpoint reads resource filtered by tenant_id and status, ordered by updated_at DESC, and returns each row plus the owner's display name from app_user and the actor of that resource's latest resource_revision. p99 is 55 ms at 10 rows per page and 1.4 s at 200. Database telemetry shows 401 statements per request, each under 1 ms, and nothing in the slow-query log. Diagnose the cause and give the fix, stating the statement count per request and the p99 you expect afterwards.

Approach

Read the counters before forming a theory. 401 statements for 200 rows is one driver query plus two per row, and sub-millisecond execution with an empty slow-query log rules out a bad plan. The time is round trips, which is why it is invisible in every per-query metric and scales with rows returned rather than with filter selectivity.
Name the two per-row statements from their normalised text: a single-row app_user lookup by user_id, and a resource_revision lookup by resource_id ordered by version DESC LIMIT 1. Confirm by dropping those two response fields and watching the statement count fall to one. That locates the calls in the serialisation layer, not the repository.
Check that the arithmetic accounts for the whole gap. Measure one round trip to the replica in isolation; 400 trips at roughly 3 ms of network plus 0.2 ms of execution is about 1.3 s on top of a 55 ms baseline, which matches. If the multiplication had fallen short, the N+1 would only be part of the story and you would keep looking.
Batch both lookups. Collect owner_user_ids and resource_ids from the driver query, then issue WHERE tenant_id = $1 AND user_id = ANY($2) for the users, and PostgreSQL's SELECT DISTINCT ON (resource_id) ... WHERE resource_id = ANY($2) ORDER BY resource_id, version DESC for the latest revision, which the UNIQUE (resource_id, version) index serves directly. On an engine without DISTINCT ON, use a lateral join or a row_number window. Three statements per request at any page size.

Follow-up

The page size is capped at 200 today. What breaks first if it is raised to 2,000, and is it still this bug?
How do you stop the next N+1 from reaching production, given that no individual query is slow and the endpoint's tests pass?

Suggested practice checklist

Built from the rounds and topics Caris Life Sciences candidates report.

Day 1 — Map the Caris Life Sciences loop

Write out the reported sequence: Recruiter Phone Screen, Technical Phone Screen, Virtual On-Site Interview.
For each round, write one sentence on what it is judging, from the description above, and mark the one you are least ready for.

Deliverable: A one-page map of the 3 reported rounds, with the weakest marked.

Day 2 — Work Technical interview (general)

Spend the session on Technical interview (general), which Caris Life Sciences candidates report being tested on.
Write one worked example in Technical interview (general) and time yourself on it.

Deliverable: One timed worked example in Technical interview (general).

Day 3 — Work Technical interview preparation

Spend the session on Technical interview preparation, which Caris Life Sciences candidates report being tested on.
Write one worked example in Technical interview preparation and time yourself on it.

Deliverable: One timed worked example in Technical interview preparation.

Day 4 — Work Problem solving skills

Spend the session on Problem solving skills, which Caris Life Sciences candidates report being tested on.
Write one worked example in Problem solving skills and time yourself on it.

Deliverable: One timed worked example in Problem solving skills.

Day 5 — Answer out loud: Practical Technical Experience & Tooling

Answer aloud, timed: What software engineering tools, frameworks, and languages are you currently using in your day-to-day work, and why?
Answer aloud, timed: How do you approach choosing the right database (SQL vs. NoSQL) for a high-throughput, data-heavy application?

Deliverable: Spoken answers to 2 reported Practical Technical Experience & Tooling question(s), under time.

Day 6 — Answer out loud: Resume & Project Deep Dives

Answer aloud, timed: Walk me through the most technically challenging software project you have designed and implemented. What were the bottlenecks, and how did you resolve them?
Answer aloud, timed: Tell me about a time you had to refactor a legacy system. What was your strategy for ensuring zero downtime or data loss?

Deliverable: Spoken answers to 2 reported Resume & Project Deep Dives question(s), under time.

Day 7 — Answer out loud: Behavioral & Collaboration

Answer aloud, timed: Tell me about a time you had to collaborate with non-technical stakeholders, such as scientists or product managers, to define system requirements.
Answer aloud, timed: How do you handle disagreements with other engineers regarding technical design or code reviews?

Deliverable: Spoken answers to 2 reported Behavioral & Collaboration question(s), under time.

Behavioural preparation

Behavioural rounds judge the decision you made and what it cost.

Describe your experience with cloud platforms (like AWS or Azure) and how you have deployed scalable services

Medium · Practical Technical Experience & Tooling

Describe your experience with cloud platforms (like AWS or Azure) and how you have deployed scalable services in the cloud.

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?

Tell me about a time you had to refactor a legacy system. What was your strategy for ensuring zero downtime or

Medium · Resume & Project Deep Dives

Tell me about a time you had to refactor a legacy system. What was your strategy for ensuring zero downtime or data loss?

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?

Tell me about a time you had to collaborate with non-technical stakeholders, such as scientists or product man

Medium · Behavioral & Collaboration

Tell me about a time you had to collaborate with non-technical stakeholders, such as scientists or product managers, to define system requirements.

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?

How do you handle disagreements with other engineers regarding technical design or code reviews?

Medium · Behavioral & Collaboration

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?

Describe a time when a project's requirements changed mid-way through development. How did you adapt and ensur

Medium · Behavioral & Collaboration

Describe a time when a project's requirements changed mid-way through development. How did you adapt and ensure successful delivery?

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?

Why do you want to transition your software engineering skills into the biotech and precision medicine space a

Medium · Behavioral & Collaboration

Why do you want to transition your software engineering skills into the biotech and precision medicine space at Caris Life Sciences?

Approach

Pick a story where you made the decision, not one where you watched it.
State the situation in two sentences and spend the rest on the reasoning.
Give the blast radius: what could have broken, and what you measured.
Name the disagreement and how you resolved it with evidence.

Follow-up

What would you do differently if you ran that again?
How did you know your change caused the improvement?